Association of Fto Rs9939609 Gene Polymorphism With Insulin Resistance in Iranian Individuals With Newly Diagnosed Type 2 Diabetes

Background and aim: insulin resistance (ir) and fat accumulation in visceral adipose tissue are key players in developing type 2 diabetes (t2d). several adipose tissue derived-gene polymorphisms are related to higher body mass index (bmi), insulin resistance and t2d. the association of fat-mass and obesity-associated (fto) rs9939609 gene polymorphism with overweight/obesity and t2d is controversial. the aim of this study was to determine the association between fto rs9939609 polymorphism and insulin resistance in newly-diagnosed t2d patients. methods: the case-control study included 83 newly-diagnosed t2d patients and 85 healthy matched controls, aged 20-80 years. fasting blood glucose and insulin levels were measured by the enzymatic method and enzyme-linked-immunosorbent assay, respectively. insulin resistance was calculated using the homeostasis model assessment (homa) index. genotyping was examined using the polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp). results: there was significant differences between fto rs9939609 polymorphism and studied individuals (p=0.0001). the genetic polymorphism of fto rs9939609 (t/a) is significantly related to higher homa index (p=0.046). moreover, fto rs9939609 polymorphism was significantly positively correlated to familial history of diabetes (p=0.024). conclusion: fto rs9939609 genetic variation may change insulin metabolism and have key roles in developing t2d through insulin resistance. thus, the evaluation of this polymorphic region may be helpful for predicting type 2 diabetes.