bioinformatics evaluation of hsa-mir-139-5p signaling pathways and its associated rs56202419 function in patients with acute myeloid leukemia

Background and aim: acute myeloid leukemia (aml) is the most common acute leukemia in adults. the identification of recurrent genetic mutations, such as flt3-itd, nmp1 and aml1, has helped refine individual prognosis and guide management. the translocation t(8;21), leading to a fusion between the runx1 gene and the runx1t1 locus, was the first chromosomal translocation identified in aml.methods: to get more information we used ncbi, mirnasnp, mirbase, mirwalk2.0, david databases and kegg pathway as the bioinformatics tools.results: investigations at the rs56202419 locus indicated that an allele altered to g, which may effect on function of the mirna associated with this region. finally, hsa-mir-139-5p as one of the most important mirnas related to this gene and given the confirmation of the role of hsa-mir-139-5p in aml through bioinformatics databases, this mirna selected for this analysis.conclusion: studies on this rs56202419 have shown that when the snp locus is in the g allele, the mirna binds to it less than the wild an allele. due to the increase action of csf1r, gm-csf, mpo, il3, so block of differentiation. we predicted that a person with g allele is more susceptible to aml by increasing the expression of the aml1.