Assosiation Between Rheumatoid Arthritis and Bladder Cancer Via Th17 Cells

Background and aim: rheumatoid arthritis is a autoimmune disease that changes the activity of white blood cells which is one of the main causes of the change in the number of th17 cells. these changes can have an epigenetic, genetic, or cell mortality source.other causes of th17 cell differentiation are also noted. on the other hand, it has been shown that th17 cells are involved in bladder cancer. these cells also have anti-tumor activity as well as tumor promoting activity. according to the research, a hypothesis was established that changes in rheumatoid arthritis is involved in bladder cancer.then we decided to compare the rna-seq th17 cells for patients with rheumatoid reriite and bladder cancer. data analysis showed that the increase of th17 cells in ra patients caused the severity of this disease and the underlying breast cancer.methods: rna-seq data consisted of 30 individuals with 10 patients with rheumatoid arthritis and 10 patients with bladder cancer and 10 patients with both diseases were analyzed using geo2r. significant genes were selected and 1000 genes were isolated and finally the number was entered in string program and its network was plotted.results: it was shown that the increase of th17 cells in rheumatoid arthritis caused increased bladder cancer in some people and inflammation mediated by th17 in different stages of tumor progression has an important role.conclusion: th17 cells are also involved in autoimmune inflammation such as rheumatoid arthritis and cancers, which increase in rheumatoid arthritis causes increased bladder cancer. however, the role of th17 in antitumor activity has also been confirmed and sometimes has apoptotic effects on tumor cells.