Methylation and Expression of Myod1 Gene in Breast Cancer Tissue Blocks

Background and aim: the methylation of the myod1 gene has been assessed in various cancers. the detection of breast cancer in younger patients is highly important and myod1 methylation can use as a breast cancer prognostic factor. methods: the expression of the myod1 gene and the promoter methylation of the myod1 gene were evaluated in tissue blocks of breast cancer using qrt_pcr and ms-pcr tests, respectivelyresults: our results show that myod1 gene promoter is in hypermethylated status in malignant patients compared to benign patients (p = 0.001). also, there is a significant correlation between the increased expression of dnmt1 and the hypermethylation of myod1 gene promoter (p = 0.038).conclusion: the results show decreased expression of myod1 in malignant patients compared to benign patients (p = 0.042). also, there is a significant relationship between the expression and hypermethylation of myod1 gene promoter (p = 0.001).