association of rs7975232 snp with the risk of multiple sclerosis

Background and aim: background: multiple sclerosis (ms) is an autoimmune disease with various unknown aspects of etiology. aim: this study was aimed to evaluate the association of rs7975232 variation of the vdr gene and ms susceptibility.methods: the current experimental study was done on 101 patients with ms and 101 healthy controls. after the blood sample collection, the genomic dna was isolated by a commercial kit. the samples were genotyped by pcrrflp method.results: statistical analysis revealed that ac genotype had a significant association with the risk of ms (or=1.9798, 95% ci=1.0675 to 3.6719, p=0.0302). besides, carriers of c allele were at high risk for ms (or=1.9798, 95% ci=1.1179 to 3.5061, p=0.0192). the allelic analysis also showed that the c allele had a significant association with an elevated risk of ms (or=1.5673, 95% ci=1.0451 to 2.3504, p=0.0298).conclusion: according to our findings, rs7975232 variation can be a risk factor for ms. however, further studies with a larger sample size are necessary to obtain more accurate results.