New Polymorphism Associated With Glanzmannthrombastenia

Background and aim: glanzmann thrombasthenia (gt) is the most common and one of the most complex platelet adhesion disorders. interleukin 1 families (il-1) are the most influencing pro inflammatory cytokines. in the intron 2 region of il1rn gene, a variable number tandem repeat (vntr) sequence of 86 base pairs exists. recently, evidence has demonstrated that polymorphism in il-1 has a key role in the development and progression of numerous diseases thus the aim of current study was to find out the possible association between il1rn vntr polymorphism and gt.methods: in a case-control study we compared the il1rn pentaallelic variable number of tandem repeats (vntr) polymorphisms in 33 gt patients and 100 controls randomly sampled from the general population.results: we found 5 different types of alleles in patient group:il1rn*1 (4 repeats, 420-bp), il1rn*2 (2 repeats, 240-bp), il1rn*3 (5 repeats, 498-bp), il1rn*4 (3 repeats, 326-bp) and il1rn*5 (6 repeats, 595-bp), the results illustrated that the vntr polymorphism of il1rn gene has significantly increased the risk glanzman trombastenia (or, 2.8 [95% ci, 1.7 to 8.8]; p = 0.0000). the results showed that carriage of il1rn vntr allele has positive association with gt susceptibility.conclusion: our data suggest that vntr il1rn polymorphism may be associated with the risk of gt in a sample of iranian population. larger studies with different ethnicities are needed to find out the impact of il1rn vntr polymorphism on risk of developing gt.