The Comparison of Interactions Between Lncrnas Meg3 and Lnc-Efnb3-1 With P53

Background and aim: p53 tumor suppressor protein plays a crucial role in the regulation of the cell cycle. previous studies suggested that multiple long noncoding rnas (lncrnas) regulate the p53 pathway. maternally expressed gene 3 (meg3) and lnc-efnb3-1 are two lncrna that could interact with p53 and regulate p53 target gene expression. although the interaction of these lncrnas with p53 is well established, their interaction mode remains unclear. the present study aims to compare the interaction of meg3 and lnc-efnb3-1 with p53 using docking approaches. methods: the structure of p53 was downloaded from the protein data bank (pdb). the rnaalifold webserver was used to obtain 2d structure of meg3 and lnc-efnb3-1 from their sequences. for converting 2d to 3d structures, the rnacomposer webserver was used. finally, the docking process of lncrnas with p53 were done by hdock server. results: the docking score energies of meg3 and lnc-efnb3-1 were -352 and -342, respectively. conclusion: meg3 has a more stable interaction than lnc-efnb3-1 with p53. therefore, it is predicted that meg3 can perform its regulatory roles better in comparison to lnc-efnb3-1. we suggest supplementary studies like expression analysis to characterize their probable interferences.