Evaluation of the Expression of Rsbn1l-As1 Long Non-Coding Rna in Breast Cancer and Its Relationship With Clinicopathological Information and Reproductive Factors

Background and aim: accumulating evidence has been reported that long noncoding rnas (lncrnas) play important roles in many types of disease through competing endogenous rna (cerna) mechanism. recently, an oncogenic lncrna named rsbn1l-as1 has been recognized. though, its dysregulation and function in breast cancer (bc) is uncertain yet. the purpose of this study is to examine the rsbn1l-as1 expression and its roles in bc. methods: the expression level of lncrna rsbn1l-as1 was screened using real-time pcr. also we applied bioinformatics tools to assess the rsbn1l-as1-micrornas-mrnas network in bc with focus on erbb signaling pathway. results: lncrna rsbn1l-as1 expression in breast tumors was upregulated relative to that in breast margins. more ever, it was found that rsbn1l-as1 expression increased associated with higher tumor size. bioinformatics analysis shows that rsbn1l-as1 is a microrna (mirna) sponge which could target cell proliferation by dysregulating of erbb signaling pathway. conclusion: the present results revealed that rsbn1l-as1 expression is significantly upregulated in breast tumors. also, clinicopathological information show that rsbn1l-as1 expression is associated with large tumor size. lncrna rsbn1l-as1 could affect cell proliferation through dysregulating of erbb signaling pathway by mirnas sponge.