The Effect of Metformin Treatment on the Gender and Mortality of Diabetic Mice Offsprings

Background and aim: diabetes is a common disease that affects human health, especially mothers and their children. it leads to materialization and mortality of mice offsprings. using metformin is a common way of treating diabetes. however, it is not clear whether it can reduce gynogenesis and mortality or not. therefore, the aim of this study is to investigate the effect of metformin treatment on the gender and mortality of diabetic mice offsprings.methods: the mice were injected with 200 mg/kg of alloxan for the induction of diabetes. after inducing diabetes, they were divided into four groups. the first group included the males and females treated by alloxan and metformin which were mated with each other. in the second group, males were treated by alloxan and metformin, being mated with healthy females. the third group included the females treated by alloxan and metformin, which were mated with healthy males. and the fourth group included the males and females treated by alloxan which did not receive metformin. after treatment, mice were coupled with the male/female ratio to determine the sex ratio of their offsprings. the one way repeated anova was used for statistical analysis.results: the result showed that the number of male offsprings in all the groups was significantly more than the control group (p ? 0/05) (fig 1). in addition, the mortality of the control group was significantly more than the other groups (p ? 0/05) (fig 1).conclusion: it seems that the metformin treatment in diabetic mice can control the mortality ratio of offsprings; it also leads to producing the more males in offsprings. gender determination and population control have been human ambitions and the metformin treatment of diabetes seems to meet some of them.