In Silico Analysis of Noncoding Snps of Human Foxd3 Gene and Their Effects on Protein Functions

Background and aim: foxd3 (gensis/hf2) is an important member of fox family that is a transcriptional repressor in the carcinogenesis of many cancers via mapk/erk signaling pathway. single nucleotide polymorphisms (snps) can disrupt in tumor suppressor function of foxd3. in this study, we have analyzed the non-coding snps of foxd3 that can alter the function of this gene in cancer and disease by, using “in silico” approach. methods: we explored in the mirna snp database, and found three snps in 3ﹶ-utr that can disrupt interaction of foxd3 mrna with mirnas (gain or loss). we know that there are nine common snps in foxd3 by using the ucsc genome browser. using on the snp2tfbs database show that, one snp (rs78645479) among nine common snps can affect binding site. in addition, utrdb served to identify five important snps in the 3ﹶ-utr of foxd3 mrna that predicted to be changed polyadenylation region. results: thus, funding of this study indicate, snps in non-coding region of foxd3 gene can alter protein function. foxd3 dysfunction may decrease its suppressor effect on cancers. conclusion: it is proposed that, exploring in genetic variation and snps can be a novel marker for prognostic of various disease spatially cancers.