Changes Expression of Tmem16a in Infertile Men With Sperm Motility Problems

Background and aim: motility and morphology of sperm can effected on fertilization, tmem16a recognized as a type of ionic channel that work as a ca2+-activated cl channels and have important role as a part of transmembrane system. this gene has interference in many vital mechanisms in cell functions. tmem16a have change expression in infertile male. the present study aims to measure the expression of tmem16a and its correlation with sperm motility.methods: we selected 32 men with asthenozoospermia and 34 cases with normozoospermia based on the clinical criteria. the expressions of tmem16a in the spermatozoa were evaluated by qrt-pcr. for analyzing, kruskal-wallis test was used to compare the expression of these in the studies groups.results: expression of tmem16a in asthenozoospermia group showed significant (p<0.05) decrease expression compare with control group. our correlations analysis between tmem16a expressions with sperm parameters including normal sperm morphology and sperm motility showed a significant positive result with sperm motility in asthenozoospermia group.conclusion: our analysis results suggest the probable role of tmem16a in sperm motility and sperm normal morphology and can interference in male infertility. supplementary studies can reveal other aspect of tmem16a role in male infertility.