controlled release of cefazolin sodium antibiotic drug from electrospun chitosan-polyethylene oxide nanofibrous mats

Electrospun chitosan–polyethylene oxide (cs-peo) nanofibrous mats containing cefazolin, fumed silica (f silica) and cefazolin-loaded fumed silica nanoparticles (nps) were produced for biomedical applications the fe-sem images revealed that the f silica and f silica-cefazolin nps had average diameters of 4010 and 6015 nm, respectively also, the fibers diameters were approximately 16030, 9020 and 7015 nm for the pure cs-peo, cs-peo-1% f silica and cs-peo-1% f silica-05% cefazolin nanofibrous mats, respectively indicating addition of f silica and cefazolin loaded f silica nps to the cs-peo mat led to decreasing the nanofiber diameter the cefazolin release from mats was sharply increased within first 24 and 6 hours for the cs-peo mats including 25% cefazolin and 1% f silica-050% cefazolin but after that the drug was released very slowly the sustained drug release for cs-peo-1% f silica-050% cefazolin suggested that it was the best nanocomposite tissue/device for biomedical applications among the mats cs-peo-25% cefazolin and cs-peo-1% f silica