Study of Cross-Linking of Polymer Matrix As A Result of Neutron Bombardment of Au/Pamamg4 Composite

In this research, au/pamam composite was prepared and evaluated for inducing of radioactivity and polymer crosslinking after neutron bombardment# the pamamg4 polymer was treated with the gold anions and then, the mixture was chemically reduced by nabh4# prepared 197au/pamamg4 was bombarded by thermal neutrons in the tehran research reactor to 198au/pamamg4 be produced# prepared nanocomposites were characterized by means of ft-ir, 1h nmr, zeta-potential measurements, tem and edx analyses# the radionuclidic purity of the 198au/pamamg4 solution was determined using purity germanium (hpge) spectroscopy# and its stability in the presence of human serum was studied# this study provides the first proof of principle that 197au/pamamg4 could be succesfully bombarded with a thermal neutron of 1× 1011 neutrons/cm2/sec for 2h for producing radioactive 198au/pamamg4 throught (n, γ) reaction# structural characterization of 198au/pamamg4 exhibited presence of some crosslinking in pamam structure and agglomeration of au/pamamg4 composite particles# howevere, the stability of 198au/pamamg4 in the presence of human serum was studied and revealed that it is suitable for for radionuclide therapy applications#