Evaluation the Effect of Zif-8 Loading Onto Polyacrylonitrile Membrane For Separation of Anti-Cancer Doxorubicin From Synthetic Wastewater

Nanoparticle addition to membranes is advancing the performance of separation processes and improving the flux without jeopardizing the selectivity# in this study, interfacial polymerization synthesis method was used to create a uniform layer of zeolitic imidazolate framework-8 (zif-8) -as a ph sensitive nanoparticle- on the porous polyacrilonitrile (pan) ultrafiltration membranes to separation of doxorubicin (dox) from water# the filtration expriments showed that by loading 0#12 wt#% zif-8, the dox rejection increases from 78% for pa/pan membrane to 98% for zif-8-pa/pan membrane which could be due to the decrease in the pores size of the membranes# by changing the ph from 2 to 8, for zif-8-pa/pan membrane, dox flux increased from 6#01 to 23#53 l/m2#h and then decreased at ph =10 to 7#51 l/m2#h# this can be due to the increase in the pores size from ph = 2 to 8 and then decrease in size to ph =10# moreover, dox rejection increased from 80% to 96% by changing in ph form 2 to 8 # this may be due to electrostatic repultion betweem dox and membrane surface