Controlled Release of Ceftriaxone Sodium Drug Loaded in Chitosan Nanoparticles: Preparation and Kinetic Modeling Study

In this work, ceftriaxone sodium-loaded chitosan nanoparticles (ctx-loaded cnps) were synthesized using the ionotropic gelation method# the size of nanoparticles was obtained 265 nm using dls analysis# the entrapment efficiency of ctx inside chitosan nanoparticles was found to be 79% according to uv/vis spectrophotometry at λ=274 nm# the drug release study for free ctx and ctx-loaded cnps was performed at ph=7#4 and, a more controlled release was observed in the case of nanoparticles# kinetic modeling of drug release data at ph=7#4 was carried out based on zero-order, first-order, higuchi, and, korsmeyer-peppas models# the results confirmed a diffusion mechanism for drug release based on the korsmeyer-peppas model in which swelling and dissolution of chitosan is negligible#