بررسی پلی مورفیسم -265t>c ژن apoaiiو پلی مورفیسم های glu360his و thr349ser ژن apoaiv در افراد چاق و دارای اضافه وزن

Abstract:introduction: obesity resulted from general or local fat accumulation in body which is considered by body mass index(bmi). genetic studies have suggested that polymorphisms of genes coding for apolipoproteins are significant determinants of serum lipoprotein and lipid level in adults. apolipoproteins may be involved in inhibition of food intake following the ingestion of fat, modulating body weight. this study aims to analyze the association between apoaii -265t>c and apoaiv thr347ser, glu360his polymorphisms and risk for obesity.material and methods: the genome dna are prepared of ambiance blood from 120 obese and overweight persons and 120 normal ones with average 24 years from zanjan azad university. the genotypes were assessed by pcr-rflp methods.results: statistical analyzes from polymorphism apoaii gene -265t>c showed that there was a significant association between cc genotypes and overweight and obesity(p=0.01), also there was significant association between g allele presence(glu360) in apoaiv gene and increase bmi(p=0.02). thr347ser polymorphism had no influence on bmi.conclusions: this study revealed that the polymorphisms of apoaii and glu360his has been related to overweight and obesity in the studied population. based on the apoaii and apoaiv function we may can prevent overweight and increasing bmi by reducing the saturated fatty acids in obese people's diet, by knowing their genotype.