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a correlation between fut2 (secretor) and fut3 (lewis) enzyme activity, helicobacter pylori infection, smoking, and fast-food intake in patients presented with dyspepsia: cross- sectional study
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نویسنده
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hashem heba ezzat ,hassan marwa m. ,mostafa maged ,hassanein nagwa ,shaheen mohammed abdelmoaty ebrahim ,alwaseef mohammad abdelhameed ,alsayed hanem mohamed badawy ,adel sara ,elshweikh samah a. ,akef ahmed ,abd alrahim nosaiba m. ,altaweel eman hussein soliman ,elawady mohamed mohamed ibrahim ,aboghabsha mohammad elsayed mohammad ,alsubhi samah awad ,hegab sherif mohamed elsayed amin ,ghoname mahmod ,mashaal s.a. ,ghorab abdel-moneim mohamed ibrahim ,abdelmoniem soha saied atteya ,mohamed mohamed gharib ,gerges mariam wagih nagib ,nassef eman mostafa ,gouda nawal s. ,hegazy hanan a. ,elmanzalawy gamal ahmed ,shawkat salma a
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2026 - دوره : 8 - شماره : 6 - صفحه:1528 -1538
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چکیده
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The lewis (le) blood group system, unlike other systems, depends on soluble glycan antigens synthesized by fucosyltransferase enzymes fut2 and fut3. these antigens are implicated in host–microbe interactions, including helicobacter pylori adhesion. despite extensive global research, data on the relationship between lewis and abo blood groups, and h. pylori infection among patients remain limited. the objective of this study is to evaluate the correlation between fut2 (secretor) and fut3 (lewis) enzyme activity, h. pylori infection, smoking, and fast-food intake among patients presenting with dyspepsia. a cross-sectional study was conducted at al-azhar university hospitals between february and august 2025, including 60 dyspeptic patients. each participant provided blood, stool, and gastric biopsy samples for h. pylori detection and blood group phenotyping (abo, rh, and lewis). data were analyzed using spss version 26. quantitative variables were presented as mean ± sd, and qualitative data as frequency and percentage. associations were evaluated using chi-square tests, with p ≤ 0.05 considered statistically significant. the most frequent lewis phenotype was le(a−b+) (42%). statistical analysis revealed no significant overall association between h. pylori infection and lewis phenotype distribution (p = 0.23). however, the interpretation of this finding is limited by the observation of a biologically implausible le(a+b+) phenotype in 15% of the cohort, suggesting a potential methodological anomaly in phenotyping. no significant associations were found with abo blood group (p = 0.32), smoking (p = 0.60), or fast-food intake (p = 0.77). no statistically significant relationships were observed between h. pylori infection and abo blood group antigens, smoking, or fast-food intake among dyspeptic patients. the interpretation of the relationship with lewis antigens is confounded by the unexpected detection of the le(a+b+) phenotype, indicating a potential limitation in the phenotyping method. the findings suggest that environmental and social determinants may play a more prominent role in h. pylori transmission than the genetic or lifestyle factors measured here.
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کلیدواژه
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helicobacter pylori; lewis antigen; fut2; fut3; abo blood group; dyspepsia; smoking; fast food
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آدرس
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ain shams university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of internal medicine, egypt, mansoura university, faculty of medicine, immunology unit, clinical pathology department, egypt, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt. prince faisal cancer center, saudi arabia, al-azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, menoufia university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, tanta university, faculty of medicine, department of internal medicine and hematology, egypt, mansoura university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of hepatology, gastroenterology and infectious diseases, egypt, al-azhar university, faculty of medicine, department of hepatology, gastroenterology and infectious diseases, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, umm al-qura university, faculty of applied medical sciences, department of clinical laboratory sciences, saudi arabia, ahmed maher teaching hospital, egypt, al-azhar university, faculty of medicine, department of hepatology, gastroenterology and infectious diseases, egypt, tanta university, faculty of medicine, department of tropical medicine and infectious diseases, egypt, al-azhar university, faculty of medicine, egypt, badr university in cairo (buc), faculty of medicine, department of internal medicine, egypt, al-azhar university, faculty of medicine, department of hepatology, gastroenterology and infectious diseases, egypt, badr university in cairo (buc), faculty of medicine, department of internal medicine, egypt, al-azhar university, faculty of medicine for girls, department of internal medicine, egypt, northern border university, faculty of medicine, microbiology department, saudi arabia. mansoura university, faculty of medicine, medical microbiology and immunology department, egypt, national research centre, environment and climate change research institute, environmental and occupational medicine department, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, ain shams university, faculty of medicine, department of clinical pathology, egypt
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پست الکترونیکی
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salmass@yahoo.com
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Authors
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