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exploring the relationship between serum copeptin levels and other laboratory and radiological investigations in assessing the severity of liver cirrhosis and its complications
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نویسنده
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sayed abdelkhalek zeinab ,omar abdulmabod ,alwaseef mohammad abdelhameed ,abdelbaset nora el saeed ,morsy mai mosad ,mekheimar magdy ahmed mohamed ,ahmed howida a. ,alsayyad mohammad mossaad abd allah ,bahgat ola ahmed ,kotb fatma m ,abdelmageed neamat abdelmageed ,metwally rafik abdellatif ,mahrose hany kamal ahmed ,mosa mohamed farouk ibrahim ,mohamed eman elsayed ,nassar waleed ,yehia fatima g. ,elawady mohamed mohamed ibrahim ,mayah fatma ibrahim ismail ,shaheen mohammed abdelmoaty ebrahim ,zaghloul boshra ahmed mahmoud ,ahmed fatma abdelhamid mohamed ,metwally asmaa said abdel azeim ,alnabawy sherein m ,said salwa rashad aly ,fayad nabil ibrahim ,el-mahalawy mostafa haseeb ,elgazzar yumna a ,hegazy mohamed mousa ,abdel-halim mohamed mahmoud ,elnaghy wageih salem ,omair heba
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2026 - دوره : 8 - شماره : 4 - صفحه:779 -795
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چکیده
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Background and objective: traditional prognostic scores for cirrhosis incompletely capture real-time circulatory stress, prompting interest in copeptin, the stable c-terminal fragment of pre-vasopressin. the objective of this study is to explore the relationship between serum copeptin levels and other laboratory and radiological investigations in assessing the severity of liver cirrhosis and its complications. materials and methods: in this january-may 2025 cross-sectional study at al-azhar university hospitals, 120 cirrhotic adults (40 each with cld, dld, or he by clinical criteria) and 40 age/sex-matched controls underwent fasting blood analysis (liver biochemistry, coagulation, creatinine, sodium, and ammonia) and copeptin measurement (brand elisa). ultrasound-graded ascites were assessed by blinded radiologists. pearson/spearman correlations and paired t-tests with welch's correction analyzed stage-specific biomarker relationships. results: copeptin increased progressively from cld (5.2±1.8 ng/ml) to dld (18.6±4.3 ng/ml, p<0.001) but plateaued in he (19.1±5.1 ng/ml, p=0.91 vs dld). albumin correlated positively in cld (r=0.46) but inversely in dld (r=-0.45, both p<0.05). ammonia showed the strongest he relationship (r=0.53, p=0.017). ascites severity progressed with clinical stage (moderate/marked: 50% dld, 85% he). conclusion: copeptin's non-linear trajectory and dissociation from routine markers suggest potential utility for identifying de-compensation risk, though he plateauing warrants further study. prospective validation against mortality/tips outcomes is needed.
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کلیدواژه
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copeptin ,cirrhosis ,biomarker ,neuro-hormonal activation ,ascites
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آدرس
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cairo university, faculty of medicine, cairo university children's hospital, clinical and chemical pathology department, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university cairo, faculty of medicine for girls, department of clinical pathology, egypt, king abdullah medical city, department of plastic &reconstructive surgery, saudi arabia, al-azhar university, faculty of medicine for boys, internal medicine department, egypt, al azhar university, faculty of medicine for girls, department of radiodiagnosis and intervention, egypt, al-azhar university, faculty of medicine for boys, internal medicine department, egypt, al azhar university, faculty of medicine for girls, department of radiodiagnosis and intervention, egypt, al azhar university, faculty of medicine for girls, department of internal medicine, egypt, al-azhar university, faculty of medicine for girls, department of hepatology, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, theodor bilharz research institute, clinical chemistry department, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university cairo, faculty of medicine for girls, department of clinical pathology, egypt, suez canal university hospital, department of internal medicine and nephrology, egypt, al-azhar university cairo, faculty of medicine for girls, department of clinical pathology, egypt, al-azhar university, faculty of medicine, department of hepatogastroenterology and infectious diseases, egypt, al azhar university, faculty of medicine for girls, department of internal medicine, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, al azhar university, faculty of medicine for girls, department of radiodiagnosis and intervention, egypt, al azhar university, faculty of medicine for girls, department of radiodiagnosis and intervention, egypt, al azhar university, faculty of medicine for girls, department of radiodiagnosis and intervention, egypt, tanta university, faculty of medicine, department of internal medicine, egypt, al azhar university, faculty of medicine for girls, department of internal medicine, egypt, university, faculty of medicine, department of diagnostic radiology, egypt, al-azhar university, faculty of medicine, department of internal medicine, egypt, helwan university, faculty of medicine, department of geriatric medicine, egypt, al-azhar university, faculty of medicine, department of hepatogastroenterology and infectious diseases, egypt, suez canal university hospital, department of internal medicine and nephrology, egypt, tanta university, faculty of medicine, department of medical microbiology & immunology, egypt, cairo university, faculty of medicine, clinical and chemical pathology department, egypt
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پست الکترونیکی
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hebataair@kasralainy.edu.eg
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Authors
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