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   correlation between metallo-Ξ²-lactamase ndm-1-producing multidrug-resistant bacteria and πΆπ‘Žπ‘›π‘‘π‘–π‘‘π‘Ž species infections in patients admitted to the pediatric icu  
   
Ω†ΩˆΫŒΨ³Ω†Ψ―Ω‡ alghamdi huda saeed ,alwaseef mohammad abdelhameed ,ahmed noura abdel alim hassanin ,mohamed soma abdallah ,hassan amira hosni hassan ,elnady nermin adel ,gandor nessma h ,radwan enas elsebaee elsaid ,ali asmaa r. ,othman hala b. ,alsayed hanem mohamed badawy ,abdelrahman mohamed mahmoud abdelfattah ,alhangor ali fawzy ali ,ahmed amany m. ,salem rodina ,jaha wijdan saleh ,alqurashi bushra haidar ,alruwaili mohammed duwal ,abd el-kareem doaa m ,ahmed mohamed abdelsalam mohamed ,abd elwahab marwa khairy ,assem ahmed ali ali ,shaheen mohammed abdelmoaty ebrahim ,el-zamek hossam m. farid ,sharaf fawzia a. ,okda heba t. ,alobaidi nahed ibrahim ,omar abdulmabod ,mohammed omima sayed
Ω…Ω†Ψ¨ΨΉ journal of medicinal and pharmaceutical chemistry research - 2026 - Ψ―ΩˆΨ±Ω‡ : 8 - Ψ΄Ω…Ψ§Ψ±Ω‡ : 5 - ءفحه:1260 -1267
Ϊ†Ϊ©ΫŒΨ―Ω‡    The common issues affecting the pediatric intensive care units (picus) include multidrug-resistant (mdr) bacterial infections and invasive fungal infections. among bacterial resistance mechanisms, new delhi metallo-Ξ²-lactamase-1 (ndm-1) confers broad resistance, including to carbapenems, while candida species remain the leading cause of invasive fungal infections in critically ill children. co-infections with these pathogens complicate management and worsen outcomes; however, limited data exist on their association in pediatric populations. the objective of this study is to evaluate the correlation between ndm-1-producing mdr bacterial infections and candida species infections in patients admitted to a pediatric icu. an observational cross-sectional study was conducted in the picu of al-azhar university hospital in egypt and hassan ghazzawi hospital in saudi arabia. a total of 50 pediatric patients were admitted after complete clinical examination by pediatrician. confirmed mdr bacterial infections underwent microbiological testing for both bacteria and fungi. bacterial isolates were identified using culture and multiplex pcr for ndm-1 detection, while candida species were identified using the vitek 2 automated system. statistical analyses included the chi-square test and pearson’s correlation coefficient, with p < 0.05 considered significant. klebsiella pneumoniae was the most prevalent ndm-1-producing isolate (34.0%, n=17/50), followed by acinetobacter baumannii and pseudomonas aeruginosa (26.0%, n=13/50, each). escherichia coli showed the lowest ndm-1 positivity rate (12.0%, n=6/50). among fungi, candida albicans and non-albicans candida species (notably c. tropicalis and c. glabrata) were isolated at low frequencies. chi-square analysis revealed no significant association between ndm-1 producers and candida infections (χ² = 1.952, p = 0.162; fisher’s exact = 0.309). correlation analysis between a. baumannii ndm-1 producers and c. albicans showed a weak, non-significant negative correlation (r = –0.198, p = 0.169). this study found no statistically significant correlation between ndm-1-producing mdr bacteria and candida infections in picu patients. nonetheless, the coexistence of these pathogens remains clinically relevant due to overlapping risk factors and therapeutic challenges. larger multicenter and longitudinal studies are warranted to clarify potential interactions and inform infection control and antimicrobial stewardship strategies in critically ill pediatric populations.
Ϊ©Ω„ΫŒΨ―ΩˆΨ§Ϊ˜Ω‡ ndm-1 ,multidrug-resistant bacteria ,pediatric intensive care unit ,co-infection ,antimicrobial resistance ,πΆπ‘Žπ‘›π‘‘π‘–π‘‘π‘Ž species
Ψ’Ψ―Ψ±Ψ³ king abdulaziz hospital and oncology centre, department of microbiology, saudi arabia, al-azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, pediatric department, egypt, al-azhar university, faculty of medicine for girls, pediatric department, egypt, al-azhar university, faculty of medicine for girls, pediatric department, egypt, ain shams university, faculty of medicine, department of clinical pathology, egypt, zagazig university, faculty of medicine, department of clinical pathology,, egypt, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of medical microbiology and immunology, egypt, ain shams university, faculty of medicine, department of clinical pathology, egypt. consultant microbiology, medical laboratory department, egypt, menoufia university, faculty of medicine, department of clinical pathology, egypt, king abdulaziz university, department of anesthesia and critical care, egypt. faculty of medicine. mansoura university, department of anesthesia and surgical intensive care, egypt, al-azhar university, faculty of medicine, department of anesthesia, egypt, fayoum university, faculty of medicine, department of clinical pathology, egypt, dalhousie university, department of biochemistry and molecular biology, egypt, king faisal hospital, microbiology department, saudi arabia, king abdulaziz hospital and oncology centre, saudi arabia, prince mohammed medical city, saudi arabia, assiut university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine for boys, department of pediatric, egypt, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine, department of clinical pathology,, egypt, al-azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt. king salman abdelaziz medical city (ksamc), main lab department, saudi arabia, al-azhar university, faculty of medicine for girls, pediatric department, egypt, king khaled hospital, saudi arabia, al-azhar university, faculty of medicine, department of clinical pathology, egypt. hassan ghazzawi hospital, laboratory department, abeer medical group, saudi arabia, ain shams university, faculty of medicine, department of medical microbiology and immunology, egypt. najran university, faculty of medicine, department of microbiology, saudi arabia
ΩΎΨ³Ψͺ Ψ§Ω„Ϊ©ΨͺΨ±ΩˆΩ†ΫŒΪ©ΫŒ omi-hju34@yahoo.com
 
     
   
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