the role of mesenchymal stem cell secretome therapy for corneal endothelial damage following phacoemulsification: a literature review

Corneal endothelial damage following phacoemulsification can result in loss of corneal clarity and impair vision. this literature review aims to understand the role of the mesenchymal stem cell secretome in wound healing, which may provide a new therapeutic alternative to minimize damage. the extensive literature search focused on articles that explored phacoemulsification, the mesenchymal stem cell secretome, and the relationship between secretome content and corneal endothelial wound healing after phacoemulsification. the findings indicate that the secretome of mesenchymal stem cells contains pro-inflammatory and anti-inflammatory cytokines and growth factors, revealing new clinical opportunities. the secretome plays an immunomodulatory role and enhances the regenerative potential in the healing process of corneal endothelial damage after phacoemulsification. in theory, mesenchymal stem cell secretome can reduce apoptosis and extracellular matrix degradation and enhance regeneration in the healing process of corneal endothelial cell damage after phacoemulsification.