inflammatory immune markers and glycemic control in type 1 diabetes patients: a cross-sectional study from tripoli, libya

Type 1 diabetes mellitus (t1dm) is a chronic autoimmune condition characterized by insulin deficiency and is associated with multiple complications, particularly in cases of poor glycemic control. this study evaluated different inflammatory markers (crp, esr, and leukocyte counts) and their correlation with glycemic control and complications in libyan t1dm patients. a retrospective cross-sectional study was conducted on 84 t1dm patients in the age rage of 12-75 years in march to august 2024. all patients underwent laboratory assessments included glycated hemoglobin (hba1c), fasting blood sugar (fbs), complete blood count (cbc), erythrocyte sedimentation rate (esr), and c-reactive protein (crp) tests. statistical analysis was performed using spss version 23.0. elevated hba1c significantly correlated with esr (p=0.003), crp (p=0.001), and monocyte count (p=0.012). out of the study cohort, 37 patients (44.0%) experienced several diabetes-related complications, with retinopathy and nephropathy being the most frequently reported (10.7% each). persistent hyperglycemia exacerbates immune dysregulation and increased risk of complication, underscoring the need for integrated monitoring of glycemic and inflammatory indices in t1dm management to prevent long-term adverse outcomes.