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exploring the link between d-dimer and major adverse cardiovascular events in smokers with type 2 diabetes mellitus
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نویسنده
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omar abdulmabod ,elmalah abeer ahmed ,elkenany nasima mohamed ,elmahdy hanaa kamel ,agiba nadia ahmed ,elsherbiny eman aziz ,abdellah mai ibrahim ,elshehabi assem ahmed moustafa ,alwaseef mohammad abd elhameed ,shaheen mohammed abdelmoaty ebrahim ,hegazy hanan a. ,mekheimar magdy ahmed mohamed ,alsayyad mohammad mossaad abd allah ,ajlan mohammed ali ,kassem iman ahmed ,mahrose hany kamal ahmed ,said salwa rashad aly ,metwally mahmoud mohammed mohammed ,hassan zayed said youssef ,mayah fatma ibrahim ismail ,khedr muhammad abd elhameed ,muhammad ahmad adel abdelhameed ,ahmed al hussein mustafa zahran ,abdo ahmed ali faheem ,el-mahalawy mostafa haseeb ,elsheikh eman
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2026 - دوره : 8 - شماره : 3 - صفحه:470 -489
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چکیده
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Type 2 diabetes mellitus (t2dm) poses a uniquely elevated cardiovascular risk when combined with smoking due to synergistic effects of chronic hyperglycemia and endothelial dysfunction. with a global t2dm prevalence of 589 million (projected to reach 853 million by 2050) and cardiovascular disease (cvd) accounting for 32.2% of comorbidities, identifying reliable biomarkers for major adverse cardiovascular events (mace) is crucial. this study aimed to assess the predictive value of d-dimer for mace in smokers with t2dm, examine its association with glycemic control, and evaluate its potential role in early cardiovascular risk assessment. a retrospective study analyzed medical records of 40 smokers and 40 non-smokers with t2dm using spss. non-parametric tests were applied due to non-normal distributions (shapiro-wilk test: d-dimer, p < 0.001; hba1c, p < 0.001). a significant negative spearman correlation was found between age and stroke in smokers (r = -0.429, p = 0.006). however, logistic regression revealed no statistically significant association between d-dimer, cholesterol, hba1c, and mace (χ² = 7.752, p = 0.170). the hosmer-lemeshow test indicated acceptable model fit (χ² = 13.821, p = 0.087), but elevated d-dimer did not reliably predict mace in this cohort. while d-dimer remains a biomarker of interest, this study did not establish its independent predictive value for mace in smokers with t2dm. further large-scale, prospective studies are needed to clarify its clinical utility in this high-risk population.
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کلیدواژه
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type 2 diabetes mellitus ,d-dimer ,cardiovascular ,smokers ,major adverse cardiovascular events (mace)
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آدرس
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al azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine (for girls), cardiology department, egypt, al-azhar university, faculty of medicine (for girls), cardiology department, egypt, al-azhar university, faculty of medicine (for girls), cardiology department, egypt, al-azhar university, faculty of medicine (for girls), cardiology department, egypt, al-azhar university, faculty of medicine (for girls), cardiology department, egypt, al-azhar university, faculty of medicine (for girls), cardiology department, egypt, al azhar university, faculty of medicine, department of clinical pathology, egypt, al azhar university, faculty of medicine, department of clinical pathology, egypt, al azhar university, faculty of medicine, department of clinical pathology, egypt, national research centre, environment and climate change research institute, environmental and occupational medicine department, egypt, al-azhar university, faculty of medicine for boys, department of internal medicine, egypt, al-azhar university, faculty of medicine for boys, department of internal medicine, egypt, new najran general hospital, department of clinical pathology and blood bank, saudi arabia, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt. dr. erfan and bagedo general hospital, department of clinical pathology, saudi arabia, theodor bilharz research institute, clinical chemistry department, egypt, al-azhar university, faculty of medicine for girls, department of internal medicine, egypt, al azhar university, faculty of medicine, department of clinical pathology, egypt, al azhar university, faculty of medicine, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of internal medicine, egypt, al azhar university, faculty of medicine, department of clinical pathology, egypt, hassan ghazzawi hospital, emergency and critical care department, alabeer medical group, saudi arabia, al-azhar university, faculty of medicine, department of cardiology, egypt, al-azhar university, faculty of medicine, department of cardiology, egypt, al-azhar university, faculty of medicine, department of internal medicine, egypt, king faisal university, college of medicine, internal medicine department, egypt. tanta university hospital, college of medicine, cardiology department, egypt
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پست الکترونیکی
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emancard@y.com
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Authors
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