study of chemical composition and isolation of lupinine from aerial parts of 𝐴𝑛𝑎𝑏𝑎𝑠𝑖𝑠 𝑠𝑎𝑙𝑠𝑎 growing in central kazakhstan

The aim of the study was to determine the chemical composition and develop efficient methods for alkaloids isolation from local plant resources, in particular, anabasis salsa, with subsequent development of a technology for producing the substance for pharmaceutical purposes. a phytochemical screening analysis was carried out, including a qualitative estimate of the total phenols, flavonoids, flavonols, alkaloids, polysaccharides, saponins, and condensed tannins. as a result of phytochemical research, sesquiterpene lactones were not detected in the studied plant. therefore, through chemical composition anabasis salsa of the studies, 12 compounds (flavonoids and their glucosides and phenolic acids as well as alkaloids) were identified. all identified compounds were previously found in other species of the genus anabasis. however, most of the presented components were described for the first time for the extract of anabasis salsa. a scheme was developed for the substance isolation of the alkaloid lupinine from the extract of the aerial part of the raw material of anabasis salsa. the alkaloid lupinine was isolated from this raw material for the first time. it was experimentally established that the water-ethanol extract of the aerial part of anabasis salsa has pronounced antimicrobial activity against gram-negative test strains of escherichia coli, and weak antimicrobial activity against gram-positive bacteria, staphylococcus aureus and bacillus subtilis.