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acinetobacter baumannii blood stream infections in patients admitted to intensive care units: incidence, risk factors and future expectations
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نویسنده
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omar abdulmabod ,saleh bothayna i. ,alghamdi huda saeed ,alwaseef mohammad abdelhameed ,zohri mohamed ramadan mohamed ,muhammad ahmad adel abdelhameed ,ageel mohammed abdulgadir ,mahmoud ibrahim fadl ,abdelmottaleb neazy abdelmokhles ,abdelbaset nora el saeed ,newishy hatem mohamed ,abd el razik mohammad abd elhalem ,doha mohamed ,mohamed eman elsayed ,salem aya ali ahmed ,abdelaziz sarah younes ,negm marwa fouad ,radwan enas elsebaee elsaid ,abdelrahman mohamed mahmoud abdelfattah ,alhangor ali fawzy ali ,elsawy ahmed gamal salah ,mohammed omima sayed ,basendwa amnah saleh ,alfeky atef abd alhameed ,eid marwa ibrahim ,morsy hayam shaaban soliman ,aljaid basel musleh ayid ,nassar waleed
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2026 - دوره : 8 - شماره : 3 - صفحه:514 -529
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چکیده
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Acinetobacter baumannii is a pathogenic gram-negative bacterium known for causing severe infections in hospitalized patients, particularly those in intensive care units (icus). its resistance to multiple antibiotics contributes to the prevalence of bloodstream infections (bsis), increasing patient mortality and imposing a significant burden on healthcare systems. this study aims to determine the incidence of a. baumannii-associated bsis in adult icu patients, identify associated risk factors, evaluate antimicrobial resistance patterns, and assess patient outcomes. a retrospective observational study was conducted by reviewing the medical records of icu patients admitted to al-azhar university hospitals (egypt), hassan ghazzawi hospital – abeer medical group, and king abdulaziz hospital and oncology centre – jeddah (saudi arabia) between october 1, 2024, and march 31, 2025. fifty-four adult patients with laboratory-confirmed a. baumannii bsis were included. statistical analysis was performed using spss, incorporating descriptive statistics, chi-square tests, and t-tests to explore associations between clinical variables and outcomes. the study analyzed 54 icu patients with a. baumannii bsis. females represented a slight majority (51.9%), and 96.3% of cases were healthcare-associated infections. common comorbidities included diabetes mellitus (dm), hypertension (htn), and cardiovascular diseases (cvd). over half of the patients (55.6%) required mechanical ventilation. notably, 74% of the isolates were classified as extensively drug-resistant (xdr). the findings indicate that most a. baumannii bsis in icu patients are healthcare-associated and predominantly caused by xdr strains. risk factors include mechanical ventilation, underlying comorbidities, and inconsistent clinical data documentation. these results underscore the urgent need for improved infection control measures, robust antimicrobial stewardship programs, and enhanced medical record-keeping to reduce the burden of a. baumannii infections in critical care settings.
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کلیدواژه
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acinetobacter baumannii ,bloodstream infections ,antimicrobial resistance ,polymicrobial infections ,hospital-acquired infections ,eskape pathogens
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آدرس
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al azhar university, faculty of medicine, department of clinical pathology, egypt. hassan ghazzawi hospital, laboratory department, abeer medical group, saudi arabia, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt. king abdulaziz hospital and oncology centre, department of microbiology, saudi arabia, king abdulaziz hospital and oncology centre, department of microbiology, saudi arabia, al azhar university, faculty of medicine, department of clinical pathology, egypt, al azhar university, faculty of medicine, department of clinical pathology, egypt, hassan ghazzawi hospital, department of emergency and critical care, abeer medical group, saudi arabia, jazan university, faculty of medicine, department of surgery, saudi arabia, al-azhar university, damietta faculty of medicine, department of anesthesiology, egypt, al-azhar university, damietta faculty of medicine, department of anesthesiology, egypt, hassan ghazzawi hospital, department of emergency and critical care, abeer medical group, saudi arabia, al-azhar university, faculty of medicine, department of medical microbiology and immunology, egypt. ministry of health, huraymila general hospital, saudi arabia, al azhar university, faculty of medicine, department of clinical pathology, egypt, king abdulaziz university, king abdulaziz university hospital, department of anesthesia and critical care, saudi arabia, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt, al-azhar university, faculty of medicine for girls, department of anesthesia, intensive care and pain management,, egypt, al-azhar university, faculty of medicine for girls, department of clinical pathology, egypt, mansoura university, mansoura faculty of medicine, department of anesthesia and surgical intensive care and pain management, egypt, al-azhar university, faculty of medicine, department of anesthesia, intensive care and pain management, egypt, al-azhar university, faculty of medicine, department of anesthesia, intensive care and pain management, egypt, ain shams university, faculty of medicine, department of microbiology, egypt. najran university, faculty of medicine, department of microbiology, saudi arabia, hassan ghazzawi hospital, laboratory department, abeer medical group, saudi arabia. colorado state university, toxicology department, usa, ain shams university, faculty of medicine, department of anesthesia, intensive care and pain management, egypt, al-azhar university, faculty of medicine for girls, department of anesthesia, intensive care and pain management, egypt, al azhar university, faculty of medicine, department of anesthesia, intensive care and pain management, egypt, hassan ghazzawi hospital, department of infection prevention and control, abeer medical group, saudi arabia, suez canal university, faculty of medicine, department of internal medicine, egypt
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پست الکترونیکی
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waleedgamie2013@gmail.com
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Authors
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