developmental toxicity of sargassum polycystum ethanol extract in zebrafish embryos

The flavonoids, polyphenols, alkaloids, steroids, and tannins found in sargassum polycystum are thought to possess antioxidant qualities. the gold standard for predicting human safety is toxicity testing. the toxicity of a 96% ethanol extract of sargassum polycystum on zebrafish embryos was examined in this study. sargassum polycystum was extracted using the ultrasonic assisted extraction (uae) technique. as part of acute toxicity experiments, zebrafish eggs were exposed to five concentrations of sargassum polycystum extract for 96 hours in accordance with oecd guideline number 236. 2013. by monitoring coagulation, somite growth, talc-bud release from yolk, and heart rate, toxicity parameters (lc50) in zebrafish (danio rerio) embryos were evaluated. the lc50 value of sargassum polycystum extract was determined as 1671.998 µg/ml.