the effect of α-mangosteen on apoptosis and inflammatory responses in a wistar rat model of dental pulp inflammation

This study aimed to investigate the effects of α-mangosteen on inflammation and apoptosis in dental pulp tissue using a wistar rat model of dental pulp inflammation. the maxillary first molar dental pulp of wistar rats was used. the pulp was opened using a diamond round bur and exposed to either 12.5 µg/ml α-mangosteen or pure hydroxyethyl methacrylate (hema) solution (as a control). after 24, 48, and 72 hours of exposure, biopsies were performed to evaluate apoptosis and the presence of neutrophils, lymphocytes, and macrophages in the dental pulp tissue through histopathological analysis. α-mangosteen significantly reduced apoptosis (p<0.05) and increased the number of inflammatory cells, including neutrophils, macrophages, and lymphocytes, in dental pulp tissue at 24, 48, and 72 hours of exposure (p<0.05). α-mangosteen appears to modulate the inflammatory response and apoptosis in dental pulp tissue. a fine-tuned balance between inflammation and apoptosis is critical, as early-phase inflammation recruits cells and initiates repair, while timely resolution through regulated apoptosis ensures the transition to regeneration. this suggests potential therapeutic applications for maintaining pulp vitality