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   computational analysis of indonesian rabies vaccine enhanced by myeloid differentiation factor 88 (myd88) genetic adjuvant  
   
نویسنده ansori arif nur muhammad ,chandara nelson ,sucipto teguh hari ,kharisma viol dhea ,murtadlo ahmad affan ali ,kolesnik evgeniy ,rebezov maksim ,parikesit arli aditya ,wiradana putu angga ,widhiantara i gede ,sahadewa sukma ,durry fara disa ,jakhmola vikash ,zainul rahadian
منبع journal of medicinal and pharmaceutical chemistry research - 2024 - دوره : 6 - شماره : 9 - صفحه:1327 -1339
چکیده    Rabies remains a pervasive zoonotic disease in indonesia, necessitating innovative strategies for vaccine development. this manuscript presents an in silico study focused on the construction of a novel plasmid-based dna vaccine targeting the indonesian rabies virus (rbv) glycoprotein, augmented with myeloid differentiation factor 88 (myd88) as a genetic adjuvant. the glycoprotein of the rbv is a key immunogenic target due to its central role in viral entry and infection. myd88, a crucial component of the innate immune system, has the potential to enhance the efficacy of vaccines through the activation of innate and adaptive immune responses. in this study, we employ computational biology techniques to elucidate the structural and functional interactions between the glycoprotein, myd88, and host immune receptors, shedding light on the mechanisms by which myd88 enhances vaccine-induced immunity. by leveraging in silico methods, this study contributed to the rational design of a plasmid-based dna vaccine against rabies, with a particular focus on the indonesian context. this approach has the potential to significantly reduce the incidence of rabies cases, enhance vaccine efficacy, and pave the way for future experimental validation and clinical trials.
کلیدواژه bioinformatics ,indonesia ,medicine ,rabies virus ,vaccine development
آدرس universitas airlangga, postgraduate school, indonesia. uttaranchal university, uttaranchal institute of pharmaceutical sciences, india. , germany. division of research and development, indonesia. indonesian society for bioinformatics and biodiversity, indonesia, the indonesian society for bioinformatics and biodiversity, indonesia. indonesia international institute for life sciences, school of life sciences, indonesia, universitas airlangga, institute of tropical disease, dengue study group, indonesia, division of research and development, indonesia. universitas airlangga, faculty of science and technology, indonesia, division of research and development, indonesia. the indonesian society for bioinformatics and biodiversity, indonesia. universitas airlangga, faculty of science and technology, indonesia, russian state agrarian university, moscow timiryazev agricultural academy, russia, v. m. gorbatov federal research center for food systems, department of scientific research, russia. ural state agrarian university, faculty of biotechnology and food engineering, russia, indonesia international institute for life sciences, school of life sciences, indonesia, universitas dhyana pura, faculty of health and science, research group of biological health, study program of biology, indonesia, universitas dhyana pura, faculty of health and science, research group of biological health, study program of biology, indonesia, universitas wijaya kusuma surabaya, faculty of medicine, indonesia, universitas pembangunan nasional “veteran” jawa timur, faculty of medicine, indonesia, uttaranchal university, uttaranchal institute of pharmaceutical sciences, india, universitas negeri padang, faculty of mathematics and natural sciences, department of chemistry, indonesia. universitas negeri padang, center for advanced material processing, artificial intelligence and biophysics informatics (campbiotics), indonesia
پست الکترونیکی rahadianzmsiphd@fmipa.unp.ac.id
 
     
   
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