the differences of serum levels of sflt-1, plgf, and sflt-1/plgf ratio throughout daytime and nighttime in women with severe preeclampsia at 30-34 weeks of pregnancy: a pilot study

Preeclampsia is identifiable by an imbalance of angiogenic factors, which entails elevated levels of sflt-1 and a reduction of plgf levels. in addition to disruptions in circadian rhythms, preeclamptic individuals may exhibit daytime and nighttime alterations in sflt-1, plgf, and the sflt-1/plgf ratio. this study aims to assess the differences in daytime and nighttime concentrations of sflt-1, plgf, and the sflt-1/plgf ratio in severe preeclamptic women between 30 and 34 weeks of gestational age. this cross-sectional study was conducted at dr. soetomo public academic hospital and airlangga university hospital in surabaya, involving ten pregnant women at 30-34 weeks of gestation, all diagnosed with severe preeclampsia. samples of blood were drawn in the morning at 08:00, followed by the evening at 20:00. the study found no significant differences in serum levels of sflt-1 (5.99 ± 3.29 vs. 6.82 ± 4.09 pg/ml), plgf (85.5 [37-312] vs. 72 [35-437] pg/ml), and the sflt-1/plgf ratio (48.5 [6-233] vs. 58.5 [3-345] pg/ml) between day and night (p > 0.05). the results suggest that the circadian rhythm does not notably influence the serum levels of anti- and proangiogenic substances in confirmed severe preeclampsia.