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serum matrix metalloproteinase 7 (mmp-7) and liver function in biliary atresia
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نویسنده
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setyoboedi bagus ,prihaningtyas rendi aji ,irawan muhammad ,octariyandra syania mega ,arief sjamsul
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2024 - دوره : 6 - شماره : 7 - صفحه:990 -996
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چکیده
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Biliary atresia is one of the main factors leading to the need for liver transplantation in children. currently, there is no non-invasive approach to diagnosing biliary atresia and differentiating it from other causes of cholestasis. this study aimed to evaluate matrix metalloproteinase 7 (mmp-7) levels as a diagnostic biliary atresia biomarker and its correlation with laboratory parameters. this cross-sectional study included infants with biliary atresia admitted to dr. soetomo general academic hospital, surabaya. blood samples, as well as baseline clinical and demographic data, were collected when admitted. mmp-7 levels were evaluated by enzyme-linked immunosorbent assay. there were 85 infants with biliary atresia, mean age 11 (7-35) weeks, 46 (54.1%) boys, with the onset of jaundice at 2 (1-20) weeks. the mmp-7 levels were 1.91 (0.39 - 9.95) ng/ml, albumin 4.06 (1.41 - 4.79) g/dl, aspartate aminotransferase (ast) 235.37 ± 130.48 u/l, , alanine aminotransferase (alt) 143.2 (30 - 641) u/l, gamma-glutamyl transpeptidase (ggt) 361 (23.9-3746) u/l, direct bilirubin 8.75 ± 4.28 mg/dl, and total bilirubin 12.34 ± 6.36 mg/dl. mmp-7 showed a positive correlation with albumin levels (r=0.232; p=0.033), but correlated negatively with ast (r=-0.252; p=0.020) and alt (r=-0.275; p=0.011) levels. direct or total bilirubin, hemoglobin, leukocyte, platelet, and coagulation function levels were not associated with mmp-7 (p>0.05). there is a positive correlation between mmp-7 and albumin, but the relationship between mmp-7 and serum transaminases is reversed. mmp-7 may be used as a non-invasive diagnostic marker for biliary atresia.
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کلیدواژه
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mmp-7 ,biliary atresia ,albumin ,transaminases enzyme
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آدرس
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universitas airlangga, dr. soetomo general academic hospital, department of child health, indonesia, universitas airlangga, dr. soetomo general academic hospital, department of child health, indonesia, universitas brawijaya, saiful anwar general academic hospital, department of child health, indonesia, universitas airlangga, dr. soetomo general academic hospital, department of child health, indonesia, universitas airlangga, dr. soetomo general academic hospital, department of child health, indonesia
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پست الکترونیکی
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sjamsul.arief@yahoo.co.id
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Authors
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