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a review of cancer-related hypercalcemia: pathophysiology, current treatments, and future directions
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نویسنده
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ansori arif nur muhammad ,widyananda muhammad hermawan ,antonius yulanda ,murtadlo ahmad affan ali ,kharisma viol dhea ,wiradana putu angga ,sahadewa sukma ,durry fara disa ,maksimiuk nikolai ,rebezov maksim ,zainul rahadian
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2024 - دوره : 6 - شماره : 7 - صفحه:944 -952
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چکیده
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Cancer-related hypercalcemia is a common metabolic complication seen in patients with advanced malignancies, affecting 10-30% of all cancer patients. it is associated with significant morbidity and mortality, highlighting the need for a comprehensive understanding of its pathophysiology and effective treatment strategies. the pathophysiology of cancer-related hypercalcemia involves the dysregulation of calcium homeostasis, primarily through the production of parathyroid hormone-related protein (pthrp) by malignant cells. moreover, it may associated to the stimulation of osteoclast activity resulting in increased bone resorption and release of calcium into the bloodstream. in addition, certain tumors can directly stimulate osteoclast activity and cause bone destruction. dysregulation of renal calcium handling also contributes to hypercalcemia in cancer patients. however, future research directions in cancer-related hypercalcemia aimed to elucidate tumor-specific mechanisms, identify novel therapeutic targets, and develop personalized treatment approaches. combination therapies, biomarkers, and predictive factors can enhance treatment efficacy and guide clinical decision-making. furthermore, the focus on supportive care, psychosocial support, and palliative measures is essential to optimize patient comfort and quality of life. improved imaging techniques, studies in pediatric populations, and investigations into long-term outcomes are also warranted. advancements in these areas will contribute to better management and outcomes for cancer patients with hypercalcemia.
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کلیدواژه
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cancer-related hypercalcemia ,cancer biology ,medicine ,pathophysiology ,treatment strategies
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آدرس
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universitas airlangga, postgraduate school, indonesia. uttaranchal university, uttaranchal institute of pharmaceutical sciences, india. division of research and development, jalan tengah, indonesia. european virus bioinformatics center, germany. indonesian society for bioinformatics and biodiversity, indonesia, universitas brawijaya, faculty of mathematics and natural sciences, indonesia, university of surabaya, faculty of biotechnology, indonesia, division of research and development, jalan tengah, indonesia. universitas airlangga, faculty of science and technology, department of biology, indonesia, division of research and development, jalan tengah, indonesia. universitas airlangga, faculty of science and technology, department of biology, indonesia, universitas dhyana pura, faculty of health and science, research group of biological health, study program of biology, indonesia, universitas wijaya kusuma surabaya,, faculty of medicine, indonesia, universitas pembangunan nasional “veteran” jawa timur, faculty of medicine, indonesia, yaroslav-the-wise novgorod state university, institute of medical education, russia, v.m. gorbatov federal research center for food systems, department of scientific research, russia. ural state agrarian university, faculty of biotechnology and food engineering, russian, universitas negeri padang, faculty of mathematics and natural sciences, center for advanced material processing, artificial intelligence, and biophysic informatics (campbiotics), department of chemistry, indonesia
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پست الکترونیکی
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rahadianzmsiphd@fmipa.unp.ac.id
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Authors
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