>
Fa   |   Ar   |   En
   a spotlight on gamma-mangostin: exploring its potential as antiviral agents  
   
نویسنده ansori arif nur muhammad ,murtadlo ahmad affan ali ,kharisma viol dhea ,muchtaromah bayyinatul ,tamam muhammad badrut ,turista dora dayu rahma ,rosadi imam ,jakhmola vikash ,parashar tarun ,saklani taru ,rebezov maksim ,zainul rahadian ,purnobasuki hery ,fadholly amaq ,kusala muhammad
منبع journal of medicinal and pharmaceutical chemistry research - 2024 - دوره : 6 - شماره : 1 - صفحه:62 -71
چکیده    The global health landscape has seen an upsurge in viral diseases, underlining the urgency for novel antiviral therapies. this mini-review illuminates the potential antiviral capabilities of gamma-mangostin, a xanthone derivative derived from the pericarp of the garcinia mangostana fruit. gamma-mangostin’s mechanisms of action are multifaceted, displaying inhibitory effects on viral entry into host cells, disrupting essential cell signalling pathways for viral replication, and enhancing the host’s immune response via antiviral cytokine stimulation. this compound has demonstrated significant in vitro efficacy against numerous viruses, including influenza a virus, herpes simplex virus, and hepatitis c virus, and emerging preliminary research suggests potential utility against sars-cov-2. its broad-spectrum antiviral properties and low cytotoxicity earmark gamma-mangostin as a promising candidate for future antiviral agent development. however, rigorous investigation is required to determine its pharmacokinetics, bioavailability, and safety profile. with the escalating burden of viral diseases, gamma-mangostin could represent an important tool in the armamentarium for disease management, contingent upon further study. this review provides an overview of current research into gamma-mangostin’s antiviral potential and the challenges to its therapeutic development.
کلیدواژه gamma-mangostin ,garcinia mangostana ,antiviral ,virus
آدرس universitas airlangga, postgraduate school, germany, generasi biologi indonesia foundation, indonesia, generasi biologi indonesia foundation, indonesia, universitas islam negeri maulana malik ibrahim, master program of biology, indonesia, generasi biologi indonesia foundation, indonesia, generasi biologi indonesia foundation, indonesia, mulawarman university, faculty of mathematics and natural sciences, department of biology, indonesia, uttaranchal university, uttaranchal institute of pharmaceutical sciences, indonesia, uttaranchal university, uttaranchal institute of pharmaceutical sciences, india, uttaranchal university, uttaranchal institute of pharmaceutical sciences, india, v. m. gorbatov federal research center for food systems, department of scientific research, indonesia, universitas negeri padang, center for advanced material processing, indonesia, universitas airlangga, faculty of science and technology, department of biology, indonesia, ipb university, school of veterinary medicine and biomedical sciences, indonesia, national research and innovation agency, research center for veterinary sciences, indonesia
پست الکترونیکی khaliimkusala@gmail.com
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved