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   astragaloside interaction of astragalus plant extract (astragalus) on adrenergic receptor alpha-2 as regulation of sympathetic nervous system activity  
   
نویسنده zainul rahadian ,novaliendry dony ,samala agariadne ,oktavia budhi ,yang cheng-hong ,purnamasari devi ,maahury mirella ,rollando ,verawati rismi ,ghifari muhammad ,albari muhammad ,ghifari muhammmad ,azhari putri ,mandeli riso
منبع journal of medicinal and pharmaceutical chemistry research - 2023 - دوره : 5 - شماره : 12 - صفحه:1137 -1148
چکیده    This research aims to study the interaction between astragaloside, astragalus plant extract, and adrenergic receptor alpha-2 as a regulation of sympathetic nervous system activity. the research methods used include the use of pymol, pyrex, protein plus, and lipinski rule software for molecular analysis and protein structure characterization. the results showed that astragaloside had a binding affinity of -6.4. in addition, rmsd was found to be 0, 2.515, and 2.703, which indicated the success of astragaloside in interacting with adrenergic receptor alpha-2. analysis using protein plus showed an interaction between astragaloside and adrenergic receptor alpha-2. lipinski analysis showed that astragaloside has a mass of 618, 10 hydrogen bond donors, 17 hydrogen bond recipients, a logp of -0.0197, and a molar reactivity of 127.710. these findings provide further understanding of the mechanism of astragaloside’s interaction with adrenergic receptor alpha-2, which could potentially regulate sympathetic nervous system activity. this study contributes to the therapies development based on astragalus plant extracts for effective regulation of sympathetic nervous system function.
کلیدواژه astragaloside ,astragalus ,adrenergic receptor alpha-2 (adra2) ,sympathetic nervous system ,molecular interactions
آدرس universitas negeri padang, faculty of mathematics and natural sciences, department of chemistry, indonesia, universitas negeri padang, faculty of engineering, department of electronics engineering, indonesia, universitas negeri padang, faculty of engineering, department of electronics engineering, indonesia, universitas negeri padang, faculty of mathematics and natural sciences, department of chemistry, indonesia, national kaohsiung university of science and technology, electronic department, taiwan, universitas awal bros, faculty health, department of radiology, indonesia, pattimura university, faculty of mathemetics and natural sciences, department of chemistry, indonesia, universitas ma chung, faculty of health sciences, department of pharmacy program, indonesia, universitas negeri padang, faculty of mathematics and natural sciences, department of chemistry, indonesia, universitas brawijaya, faculty of computer sciences, department of information technology, indonesia, universitas brawijaya, faculty of computer sciences, department of information technology, indonesia, universitas brawijaya, faculty of computer sciences, department of information technology, indonesia, universitas andalas, faculty of agricultural technology, department of agricultural technology, indonesia, universitas negeri padang, department of environmental science, postgraduate programme, indonesia
پست الکترونیکی risosarimandelii@gmail.com
 
     
   
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