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   correlation between dengue virus serotypes with shock and without shock in dengue virus infection  
   
نویسنده wrahatnala billy jordan ,aryati aryati ,husada dominicus ,wardhani puspa ,sunari i. gusti agung ayu eka putri ,hakim faradila khoirun nisa ,indrasari yulia nadar ,rohman ali
منبع journal of medicinal and pharmaceutical chemistry research - 2025 - دوره : 7 - شماره : 6 - صفحه:1096 -1110
چکیده    The increasing number of dengue hemorrhagic fever (dhf) cases in jember regency, indonesia, in 2019 resulted in high mortality. this study aimed to explain the relationship between dengue virus (denv) serotype and dengue virus infection (dvi) severity and denv serotype with shock and non-shock manifestations in dvi. this type of study is an experimental laboratory with a retrospective horizontal design. the study population included patients aged 1-65 years old with suspected dvi—the sampling technique used consecutive sums. the study sample consisted of dvi patients who met the inclusion and exclusion criteria and were willing to sign informed consent. the extraction made the serological diagnosis of denv rna. serotype determination is performed by isolating virus cultures and checking for denv serotype detection by rt-pcr in real-time. data analysis was done using chi-square with stata 14.0 application. the results showed a statistically significant relationship between the denv serotypes and incidence and absence of shock in dvi. still, there is no relationship between denv serotypes and dvi severity. serotype den-2 (40%) induces shock manifestations on dvi. conclusion: there was an association between denv serotype and shock and non-shock manifestations in dvi, but no relationship between denv serotype and severity of dvi. the government of jember regency has taken preventive and specific measures to prevent the area from experiencing increased morbidity and high mortality rates from dvi.
کلیدواژه dengue virus ,serotype ,dengue hemorrhagic fever ,dengue shock syndrome
آدرس airlangga university, medical faculty, master program of tropical medicine, indonesia, airlangga university, department of clinical pathology, medical faculty, indonesia, medical faculty– airlangga university, department of pediatrics, indonesia, airlangga university, department of clinical pathology, medical faculty, indonesia, airlangga university, medical faculty, clinical pathology specialist education doctor program, indonesia, airlangga university, medical faculty, master program of tropical medicine, indonesia, airlangga university, medical faculty, department of clinical pathology, indonesia, airlangga university, science and technology faculty, department of chemistry, indonesia
پست الکترونیکی alirohman@fst.unair.ac.id
 
     
   
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