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microneedling with platelet-rich plasma versus using platelet-rich plasma alone for the treatment of atrophic acne scars: a comparative study on clinico-histological features
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نویسنده
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abuamara tamer m.m ,el-haroun hala ,nasr mohamed ,elsharaway ayman f. ,fayed ebrahim m. ,hablas mohamed g.a. ,elzahaby osama m. ,el-nawasany moustafa a.h. ,elsayedf almoatazbellah m. ,mohamed sameh fawzy f. ,shawky ahmed ,ammar amr m. ,amer mohamed a. ,mamdouh hassan ,elrewiny emad ,risha basma e.m. ,elsadiq hala m. ,salama omar abd-elaziz mohammad ,ibrahim ahmed nabil maawad ,sonbol mohamed mostafa ,kaabo hassan fathy ,aladl ahmad s. ,hassan dina a.a ,ibrahim hany sabry ahmed ,elmaleek doaa abd
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منبع
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journal of medicinal and pharmaceutical chemistry research - 2025 - دوره : 7 - شماره : 6 - صفحه:1278 -1292
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چکیده
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Platelet-rich plasma (prp) is an autologous concentrated platelet preparation that could be helpful in the medical care of atrophic acne scars by stimulating collagen synthesis. skin micro-needling is a method in which a sterile puncture of the skin leads to the release of growth factors. the combination of skin micro-needling with prp may improve the efficacy of both procedures. the objective of this study was to compare the effectiveness and safety of prp as a monotherapy for atrophic acne scars with those of micro-needling with prp. forty-eight patients with atrophic acne scars were randomly assigned to two equal groups: group a received an intradermal injection of prp, and group b was treated with combined skin needling and prp. each participant underwent three months of therapy (four sessions at 1-month intervals). the participants were evaluated before and 3 months after therapy using photography, the goodman and baron qualitative grading approach, participants’ satisfaction, and local biopsies. group b demonstrated a significant improvement over group a by employing all of the approaches outlined above. the results showed that the combination of micro-needling and prp produces higher results across all assessment methodologies. there were no statistically significant differences in side effects between our treatment regimens. although a single therapeutic procedure involving locally injected prp gives good results in the management of atrophic post-acne scars, combining micro-needling with prp is more effective. however, both treatments are well-tolerated in all types of atrophic acne scars.
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کلیدواژه
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acne scars ,micro-needling ,platelet-rich plasma ,special stain ,histology
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آدرس
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al-ahliyya amman university (aau), center of oral diseases studies, faculty of dentistry, egypt, al-ryada university for science & technology, egypt, al-azhar university, faculty of medicine, histology department, egypt, al-azhar university, faculty of medicine, histology department, egypt, al-azhar university, faculty of medicine, histology department, egypt, suez university, faculty of medicine, histology and cell biology department, egypt, al-azhar university, faculty of medicine, histology department, egypt, al-azhar university, faculty of medicine, histology department, egypt, zarqaa university, faculty of dentistry, department of basic medical and dental sciences, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine for girls, dermatology and venerology department, egypt, al-azhar university, faculty of medicine for girls, dermatology and venerology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine, histology department, egypt, al-azhar university, faculty of medicine, venerology and andrology department, egypt, al-azhar university, faculty of medicine for girls, histology department, egypt, al-azhar university, international islamic center of population studies and research, venerology and andrology department, egypt, al-azhar university, faculty of medicine for girls, dermatology and venerology department, egypt
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پست الکترونیکی
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doaaabdelmelek.medg@azhar.edu.eg
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Authors
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