toxicological assessment of the effect of cadmium chloride on quantitative and qualitative parameters of spermatogenesis in vivo

The effect of cdcl2 on the seminal glands of male white rats during postnatal ontogenesis was studied using histological, morphometric and statistical research methods. for the experiment, 50 white mongrel sexually mature male rats were used as a biological test object in the work. rats of the experimental group were orally administrated with cdcl2 for 7 days at a dose of 5 mg/kg/day. it was found, that cdcl2 leads to significant decrease of morphological and morphometric parameters of seminal glands of male white rats. it was revealed, that under the influence of cdcl2, the shape of the spermatozoids head changes, its area and neck diameter decrease, and the length of the tail part increases. it is important to note, that there was a decrease in the spermatogenesis index by 10.24% and the relaxation index (spermatogenesis intensity) by 4.46% in experimental rats, which is an indicator of seminal glands low activity. moreover, cdcl2 treatment led to decrease in the total concentration of spermatozoids in the ejaculate, the concentration of live spermatozoids, as well as their viability, respectively, by 50.63%, 81.68%, and 53.05%. at the same time, there was an increase in the concentration of dead spermatozoids in the ejaculate by 60.68%. thus, the results obtained show the mechanism of the cdcl2 effect on morphological and morphometric parameters, as well as functional indicators of the productivity of seminal glands in laboratory rats.