comparative analysis of low-intensity resistance training with blood flow restriction and moderate-intensity resistance training on insulin-like growth factor-1 serum levels in elderly women

As individuals age, there is a decline in muscle mass in insulin-like growth factor-1 (igf-1), which contributes to skeletal muscle loss and an increased risk of falls. previous research showed that low-intensity resistance training with blood flow restriction (li-bfr) has significantly improved igf-1 levels. li-bfr can serve as an alternative to increase muscle strength and size, which is comparable to moderate-intensity resistance training (mi-rt). this study aimed to analyze the comparison effect of li-bfr and mi-rt on igf-1 levels in elderly women. the study included a sample of 22 elderly women who met the inclusion criteria and were randomly assigned to two groups. the mi-rt group underwent moderate-intensity training (≥40-60%1rm), while the li-bfr group performed low-intensity exercises (20-30%1rm) with blood flow restriction applied to the lower extremities at a pressure of 50 mmhg or 40% arterial occlusion pressure (aop). the intervention period was 6 weeks, with serum igf-1 levels being assessed prior to and following the intervention. the results revealed no substantial difference in igf-1 levels in mi-rt (p=0.19), li-bfr (p=0.85), and delta between both groups (p=0.6). low-intensity resistance training with blood flow restriction is as effective as moderate-intensity training in elderly women.