the effect of administering salted fish extract as a model of pregnancy hypertension in mus musculus balb-c strain through blood pressure and urinary protein measurements

Globally, hypertension complicates approximately 6-8% of all pregnancies. hypertension is a risk factor for the occurrence of preeclampsia are 1.591 times more likely to experience preeclampsia compared to those without a history of hypertension. pregnant women are at risk of developing hypertension if there is a high concentration of salt (nacl) in their blood, leading to an increase in plasma sodium levels, also known as hypernatremia, which causes the blood plasma to become hypertonic. this study aims to demonstrate the effects of salted fish extract administration as a model of pregnancy hypertension in balb-c strain mus musculus mice through blood pressure and urine protein measurements. this study utilized a true experimental design with a post-test only with a control group design. the experimental subjects were pregnant female mus musculus balb-c mice at a gestational age of 1 day. data analysis was conducted using the non-parametric kruskal-wallis test with spss 22 software. there were significant differences observed between the negative control group, positive control group (anti qa-2), groups given salted fish extract with nacl content of 17.5 mg, 52.6 mg, and 87.8 mg, and the nacl dose of 52.6 mg, in terms of systolic blood pressure, diastolic blood pressure, mean arterial pressure (map), and urine protein levels. the administration of salted fish extract as a model of pregnancy hypertension has an impact on blood pressure and urine protein levels.