main clinical and laboratory features of children with sepsis: a single-center prospective study in central vietnam

Sepsis, a life-threatening inflammatory response to infection, is a major cause of death in children worldwide, with a higher mortality rate in developing countries due to delayed diagnosis and treatment. this study investigates the clinical, laboratory features and prognostic factors of sepsis in children to improve outcomes. this prospective observational study was done in april 2022 to july 2023 at pediatric centre of hue central hospital examined 69 pediatric sepsis cases. sepsis clinical features and prognostic variables in 69 children were examined in this study. males outnumbered females (1.2:1) at 32 months, the median age. most infections were respiratory (30.4%), followed by skin/soft tissue (27.5%) and gastrointestinal tract (26.1%). about 30% of patients had early severe symptoms such hypotension, weak pulse, and protracted capillary refill. at 37.7%, respiratory and cardiovascular organs were most damaged, followed by hematologic (30.4%). total mortality was 20%, with 35% within 24 hours. multiple organ dysfunction and reduced consciousness predicted bad outcomes the most (or 65.6 and 18.7). among laboratory markers, thrombocytopenia was the biggest death risk factor (or 17.8). to improve paediatric sepsis outcomes, early detection of severe symptoms and risk factors is crucial. despite diverse presentations and a high mortality rate (29%), early identification of multiple organ dysfunction, impaired consciousness, and low platelets in pediatric sepsis is crucial for improved survival through aggressive management.