synthesis, characterization, and evaluation of antibacterial and antioxidant activity of 1, 2, 3-triazole, and tetrazole derivatives of cromoglicic aid

The present work includes preparing new compounds of 1, 2, 3-triazole, and tetrazole based on cromoglicic acid and using them as anti-bacterial and ant-oxidant agents. the mentioned compounds were prepared using click chemistry; triazole rings were reacted with azide (terminal alkyne of cromoglicic acid) in the presence of copper as a catalyst. the modified compounds were characterized using different techniques such as ftir, 1h-nmr, and 13c-nmr. then, the antioxidant and antibacterial activities of the synthesized compounds were experimentally examined in vitro versus two kinds of bacteria (escherichia coli (gram-negative bacteria) and staphylococcus aureus (gram-positive bacteria)).the dpph (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical method was used to measure the antioxidant activity of the prepared compounds, while the antibacterial activity was examined using the diffusion method. the obtained results for all prepared compounds were good as an antioxidant in comparison with ascorbic acid.