synthesis and characterization of some new prodrug polymer based on chitosan with tertiary-butyl acrylate and study some application

Chitosan is a product of the deacetylation of chitin and widely found in the nature. therefore, the modification of chitosan has been an important aspect of chitosan research. chitosan have a good solubility, ph-sensitive target also increasing number of delivery systems. the study synthesized rization of some chitosan- amoxicillin h1 and chitosan-diclofenac h2 prodrug and release of drug. the structure of h1 and h2 was analyzed by ft-ir, 1h-nmr, and character tga. drug release of prodrug polymers was measured in three different ph (ph=2, 7, and 8) at 37 ℃. from the obtained results, these polymers appear good drug release in a basic medium for an ester bond of polymers as compared with amide bond of the other polymer.