synthesis and characterization of some new heterocyclic compounds (hydroqinazoline and thiazinone) prepared from schiff bases derived from flucytosine drug and study of biological activity

A series of some new heterocyclic six–membered compounds has been synthesized from flucytosine drug, containing a terminal primary amine group, and was used to prepare a number of new schiff base compounds bearing the numbers (a1-a4) through interaction with different aldehydes and ketones and using ethanol absolute as a solvent. after that, it was possible to prepare several organic compounds using schiff bases (a1-a4) prepared in the first step, which contain azomethine group react with (2-aminobenzoic acid and 2-mercaptobenzoic acid) to prepare hydroqinazoline (a5-a8) and thiazinone derivatives (a9-a12). these reactions are followed by tlc and the measurement of melting points for the derivatives. these compounds were determined by ft-ir and by 1h-nmr and 13c-nmr spectra, along with studying the biological activity of the prepared derivatives.