association of serum apelin and atherogenic indices in patients with primary thyroid diseases

Apelin is an adipocytokine secreted from adipocytes. although much research has been conducted on apelin, no or few reports are there about its association with atherogenic indices in patients with thyroid dysfunctions. the aim of this study is to investigate the association between serum apelin and atherogenic indices. a total of 177 participants were included in the current study (43 controls and 124 patients with thyroid dysfunction). serum apelin and lipid profile tests were determined and atherogenic indices were calculated for each participant. higher concentrations of apelin level in hyperthyroidism were compared with control groups and hypothyroidism. all types of an atherogenic indices indicated a significant increase in hypothyroidism more than hyperthyroidism and control groups, the atherogenic indices (aip, cri-i, cri-ii, ac, and chol indices) had more diagnosis accuracy than apelin in a diagnosis of hypothyroidism group, despite of that apelin had more diagnosis accuracy than atherogenic indices (aip, cri-i, cri-ii, ac, and chol indices) in a diagnosis of hyperthyroidism group. the apelin was significantly increased in hyperthyroidism compared with hypothyroidism.