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Synthesis and Characterization of New 4,6-Dimethoxy-1h-Indole Derivatives As Antibacterial and Antitumor Agents
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نویسنده
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Mubarak Hayfaa A. ,Hussein Alaa Ali ,Jawad Wisam Abdul Jaleel ,Karhib Mustafa M. ,Abd Alrazzak Nour ,Kareem Mohanad Mousa ,Naje Ahmed Samir
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منبع
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Eurasian Chemical Communications - 2023 - دوره : 5 - شماره : 5 - صفحه:411 -424
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چکیده
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New heterocyclic compounds derived from 4,6-dimethoxy-1h-indole were synthesized. 4,6-dimethoxy-1h-indole was reacted with chloroacetic acid to produce compound (r1) which used as starting material to synthesized pyrazole, isoxazole, and pyrimidine derivatives respectively. compound (r1) reacted with urea and thiourea to produce diazetidin-2-one (r2) and diazetidine-2-thione (r3). on the other hand, (r1) was combined with thiosemecabazide to produce thiadiazole (r4) which combined with benzaldehyde in acetic acid to yield schiff base compound (r5). this compound used as starting material to creation compounds (r6-r11) via reaction with hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride, acetamide, urea, and thiourea respectively. anticancer and antibacterial activity of the synthesized compounds was investigated with good results. compounds r3, r6, r9 and r11 with (nh) group demonstrated strong activity against mcf7 cells, the ic50 values range between 31.06 - 51.23 µg/ml.
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کلیدواژه
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Anticancer Activity ,Diazetidine ,Isoxazole ,Triazolidine ,Pyrazoline
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آدرس
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University Of Babylon, College Of Engineering, Chemical Engineering Department, Iraq, University Of Mosul, College Of Education For Girls, Department Of Chemistry, Iraq, University Of Babylon, College Of Science, Department Of Chemistry, Iraq, Al-Mustaqbal University College, Department Of Medical Laboratory Techniques, Iraq, University Of Babylon, College Of Science For Women, Department Of Chemistry, Iraq, University Of Babylon, College Of Science, Department Of Chemistry, Iraq, Alqasim Green University, College Of Engineering, Iraq
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پست الکترونیکی
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ahmednamesamir@yahoo.com
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Authors
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