the effect of pregabalin on the pain status of patients with disc and spinal surgeries: a systematic review of drug therapy

Pain is the physiological response of the body to tissue damage, disease itself, or visceral dilation and can occur intra- or postoperatively. pregabalin (pgb, δ-[+]-3-isobutylgaba) is structurally similar to gamma-amino butyric acid (gaba), and does not bind to gaba receptors and exerts its effects on the α2δ receptor. therefore, the aim of the present study was to evaluate the pgb effect on reducing pain in patients with disc and spinal surgeries. the search process was carried out by two researcher (one anesthesiologist and one neurosurgeon) using specific keywords lumbar spinal surgery, pain, lumbar disc herniation (ldh) surgery, lumbar laminectomy, spinal surgery, and pgb in isipubmed- scopus international databases. in the initial search, 322 articles were found, which after reviewing 16 articles were entered the final stage. of the articles included in, 6 articles were in the group of patients with spinal surgery, 3 articles were in the group of patients with ldh surgery, 7 articles were in the group of other spinal patients including lumbar discectomy, lumbar laminectomy, and other patients. in most of the reviewed articles, pgb was used to reduce the pain of patients. due to the positive effect of pgb on reducing pain in patients, it is recommended to prescribe this drug.