D-Dimer As A Diagnostic Biomarker For Pediatric/Neonatal Sepsis: A Systematic Review

Diagnosis of sepsis is made based on clinical symptoms and laboratory findings, in which the clinical symptoms may be specific or nonspecific aim of d-dimer as a diagnostic biomarker for pediatric/neonatal sepsis. the researchers extracted all papers that had been published with the aim of examining pediatric and neonatal sepsis, and then they investigated them according to the inclusion and exclusion criteria, and finally included them. after the final conclusion and removal of the repeated papers, the results were reported using data frequency distribution table. in this study, in the initial search, 176 papers were found; after the initial and final screenings, the number reached 10 papers to be included in the sr stage. the total number of patients was 2075, on whom four studies had been done on one neonatal age group and six on children’s age group. furthermore, considering hospitalization in the ward, three studies had been done in nicu, 4 in picu, and three studies in the pediatric ward. moreover, the patients’ mortality arranged from 0.9% to 52.7%. in all examined studies, it was observed that the patients with more severe clinical status or those who had died had higher levels of dd compared to other patients. in patients with more serious clinical status or those that had died, dd level was reported higher compared to the other patients. it seems that dd level can be used as a factor for disease diagnosis and prognosis of the patients.