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Spectrophotometric Determination of Phenobarbital in Pharmaceutical Preparation Using Gold Nanoparticles
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نویسنده
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Al Samarrai Eman Thiab ,Alwan Liqaa H. ,Al-Haddad Suha Abdullah Hussein ,Al Samarrai Mustafa Hamed ,Al-Obaidi Muhannad Salim Miteb ,Al Samarrai Othman Rashid
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منبع
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Eurasian Chemical Communications - 2022 - دوره : 4 - شماره : 9 - صفحه:812 -825
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چکیده
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A simple, rapid and accurate spectrophotometric method is proposed to determine phenobarbital (phb) based on the coupling of 2,6-dichloroindophenol sodium salt hydrate (dsh) with phb to give a new ligand which reacts with gold nanoparticles in alkaline medium at (30-40°c) to give an intense blue-green colored chelate complex having maximum absorption at 600nm. the optimization of the experimental conditions is described. beer’s law is obeyed at concentration range up to 5-45μg/ml with molar absorptivity 2368.797 l/mol.cm, sandell's index was 0.09803 (μg/cm²) the correlation coefficient, limit of detection and limit of quantification were 0.9984, 1.3002μg/ml and 4.3342μg/ml, respectively. the method has been successfully used to determine the phenobarbital concentration in pharmaceutical preparation.
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کلیدواژه
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Phenobarbital; 2 ,6-Dichloroindophenol Sodium Salt Hydrate; Gold Nanoparticles; Spectrophotometric Method
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آدرس
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University Of Samarra, College Of Education, Department Of Chemistry, Iraq, University Of Samarra, College Of Education, Department Of Chemistry, Iraq, University Of Samarra, College Of Education, Department Of Chemistry, Iraq, University Of Samarra, College Of Education, Department Of Chemistry, Iraq, University Of Samarra, College Of Education, Department Of Chemistry, Iraq, University Of Samarra, College Of Education, Department Of Chemistry, Iraq
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پست الکترونیکی
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othman.samarrai@uosamarra.edu.iq
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Authors
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