the influence of growth hormone on some interleukins levels in patients with growth hormone deficiency

The aim of this study is to evaluate the influence of growth hormone on some interleukins levels in patients with growth hormone deficiency by measuring and correlating many biochemical markers. blood samples were gathered from study participants to estimate levels of basal growth hormone, growth hormone after 60 min (gh2) and 90 min (gh3) induction with clonidine, respectively, insulin-like growth factor, interleukin-4, interleukin-6, and resistin. the outcomes of the anthropometric measurements of the studied groups exposed a significant (p < 0,05) differences in mean of bmi and bmi z score between the ghd and non-ghd. the outcomes presented significant (p < 0.05) decrease in levels of basal gh, gh2, gh3, and igf-1 in the ghd compared to the non-ghd. the outcomes presented a significant (p<0.05) fall in level of il-4, il-6 and resistin in the ghd compared to the non-ghd. the breakdown of the study groups revealed that males made up (53.3%) of the ghd, while females made up (46.7%), whereas the non-ghd (64.4% males and 35.6% females). the percentage of underweight in the ghd (71.1%) was lower than in the non-ghd (80%), whereas the percentage of normal weight was greater in the non-growth hormone deficiency (20%) compared to the ghd (17.8%). the distribution of the studied groups by gender displayed that non-significant (p>0.05) variances were seen in basal gh level, gh2, gh3 between males and females, igf-1 was significant (p<0.05) decreases in males compared with females.