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Assessment of Hypoxemia Status By Measuring Serum Level of Hypoxia Inducible Factor 1 Alpha in Relation To Tumor Suppression Protein P53, Estradiol and Tumor Proliferation Markers of Breast Cancer in Thi-Qar Province/Iraq
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نویسنده
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Khadem Zainab ,Al-Shammaree Shatha ,Abdulretha Mohanad
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منبع
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Eurasian Chemical Communications - 2022 - دوره : 4 - شماره : 7 - صفحه:625 -635
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چکیده
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Hypoxemia means low levels of oxygen in the blood and it alters cancer cell metabolism and causes multiple intracellular signaling pathways. investigate hypoxia status by measuring the concentration of hif-1α as a prognostic factor of hypoxia and its relation to tumor suppressor protein p53, estradiol, tumor grade, tumor size, and lymph node metastases of adult female with breast cancer. this study is a case control study which includes sixty- five adult female patients with breast mass. out of 65 patients, a 44 (68%) were with fibroadenoma in the age range of 18-42 (32.55±6.40) and the other 21 (32%) cases with breast cancer type invasive ductal carcinoma (idc) aged 32-80 (56± 14.4). most idc cases were in grade iii and sizes t2 and t3. the other 50 healthy females, as a control group were in mean age of 44.56±16.85. preoperative blood samples were collected for biochemical analysis by the elisa method. a significant elevation in serum hif-1α, p53 and e2 (p<0.001) in idc cases as compared to fibroadenoma and the control group, there was a positive relation between hif-1α, p53, and e2. hif-1 α, p53, and e2 were significantly elevated in the patients with grade iii and tumor stage t3 than grade ii and stages t2 and t1. a significant elevation was found in the subgroup of positive lnm for all preoperative serum levels of parameters compared with the negative lnm patients group. hif-1α, p53, and e2 were useful markers of invasion depth of tumor or lnm in breast cancer staging and the interactions between hif-1α, p53, and e2 signaling pathways may be of major clinical significance in cancer therapies through targeting the lowering of severity of hypoxia and angiogenesis.
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کلیدواژه
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Hypoxia; Breast Cancer; Invasive Ductal Carcinoma; Hif-1α ,Tumor Suppression Protein P53; Estradiol And Lymph Node Metastases
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آدرس
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University Of Thi-Qar, College Of Medicine, Department Of Clinical Biochemistry, Iraq, University Of Baghdad, College Of Science, Department Of Chemistry, Iraq, University Of Thi-Qar, College Of Medicine, Department Of Surgery, Iraq
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پست الکترونیکی
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zainabalsalmy11@gmail.com
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Authors
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