novel synthesis of 1,3,4 oxadiazole derivatives poly (maleimide-co-methyl acrylate) with some carboxylic acids and their biological activity

Aromatic polyimides (pis) are receiving substantial interest because of their brilliant complete properties, multipath synthesis, various processing methods and wide application fields. the current work aimed at the synthesis of a new series of 1,3,4-oxadiazole derivatives on poly (maleimid-co-methyl acylate). in first step poly (maleimidco- ma) (1) was prepared using gebrail reaction to give poly (potassium maleimid-co-methyl acrylate) (2), then it reacted with different alkyl halide to obtain compounds (3- 5) of free radical copolymerization. in the second step it was treated with pure hydrazine (99%) to give compounds (6-8). the final step was the reaction of different carboxylic acid with copoly acid hydrazide in present phosphoryl chloride to give compounds (9-23) as shown in scheme (1). all prepared compounds were characterized by softening points (ft-ir), and some of them by hnmr and thermal gravimetric analysis (tga)). further, their biological application was investigated. some of their physical characteristics are listed in tables 1 and 2.