synthesis of novel 2-(alkyl/arylamino)-2-oxo-1- (quinolin-4-yl)ethyl cinnamates through three- component reaction between an isocyanide, quinoline-4-carbaldehyde and cinnamic acid derivatives

Passerini reactions of an isocyanide, quinoline-4- carbaldehyde, and cinnamic acid derivatives in water proceed at room temperature giving 2-(alkyl/aryl amino)-2-oxo-1- (quinolin-4- yl)ethyl cinnamate derivatives in quantitative yield. the reactions are one-pot, and the products did not require any purification. this procedure offers significant advantages such as operational simplicity, mild reaction conditions, enhanced rates, cleaner reaction profiles, ease of isolation of products, and h_2o as a medium, making it a valuable protocol for synthesizing these compounds.